University of the West of England

MODULE SPECIFICATION

Code: USSJ67-30-M Title: CELLULAR PATHOLOGY B Version: 7

Level: M UWE credit rating: 30 ECTS credit rating: 15

Module type: STANDARD

Owning Faculty: Applied Sciences Field: Natural & Life Sciences

Valid from: September 2005 Discontinued from:

Pre-requisites: NONE

Co-requisites: NONE

Excluded combinations: NONE

Learning outcomes:

    • critically evaluate applications of current microscope technologies in cellular pathology.

    • demonstrate an understanding of the impact of recent research developments in cellular pathology.

    • review the application of molecular and histochemical techniques in cellular pathology.

    • discuss at an advanced level the pathology of named diseases processes.

    • to review the contribution of cytology to the investigation and diagnosis of selected diseases.

Syllabus outline:

The content below is an indicative, but not exhaustive list of the topics likely to be included in order to reflect current advances and concerns in cellular pathology. Minor changes may occur to emulate advances in the subject.

Advanced topics in microscopy.

Evaluation of preparative technologies for electron microscopy. All aspects of specimen preparation for electron microscopy including TEM, SEM and STEM. Selected topics in advanced microscopy for example; confocal microscopy. Quantitation theory in cellular pathology - instrumentation and the impact of image analysis systems. Photomicrography

Selected studies in anatomy and histology.

Advanced study of the histological structure and function of, for example, muscle, connective tissue, the central and peripheral nervous systems. The post mortem investigation in diagnosis, teaching and research. Legal procedures. Sudden infant death.

Advanced topics in non-gynaecological clinical cytology.

The investigation and differential diagnosis of sputa, CSF, ascitic fluid and other aspirated body fluids. The principles of sampling via endoscopy; an evaluation of the technologies used.; tissues that can be sampled by these means; the appearance of normal and abnormal cells thus obtained and the process of reporting the same. The development, theory and principles of FNA. The role of FNA in clinical cytology.; comparison with biopsy procedures in histopathology. FNA from unusual sites. Preparative systems in non-gynaecological cytology; safety issues; the application of tinctorial, histochemical, immunocytochemical and molecular biological technologies to non-gynaecological clinical cytology material. The role of non-gynaecological clinical cytology in hospital diagnosis; case studies.

Advanced topics in histochemical localisation.

The diagnostic role of specialised staining procedures and histochemistry. Quality control in staining procedures. Contrast enhancing procedures and histochemical localisation in electron microscopy.

Advanced topics in systemic pathology

The neurodegenerative diseases and their investigation. The pathology of, for example, muscle, the breast, the gastro-intestinal tract, the genito-urinary system, the kidney and the vascular system and their investigation by cellular pathology. Specialist issues in paediatric pathology.

Selected studies in cellular pathology

The electron microscope in diagnostic pathology.

The epidemiology of cancer. Tissue banks and tissue banking networks. The atlas of human protein expression (Sanger Institute). Molecular techniques in cellular pathology. Quality assurance, external quality assessment and quality control. Inflammatory bowel disease, The diffuse neuroendocrine system, Atherosclerosis. Gastrointestinal Stromal Tumours (GIST’s). Automation in histopathology, Solid tumour testing with FISH. Identifying the primary site of a tumour.


Teaching and learning methods:

The module will be delivered as a series of key-note lectures on topics in cellular pathology. The lectures will be designed to integrate the scientific aspects of cellular pathology with aspects of systemic pathology. The lecture sessions will provide a framework which will act as a focus for self learning by students. Seminars will be used to develop communication skills. Analytical skills of the students will be developed by the use of illustrative diagnostic problems. Students will also be encouraged to explore and directed towards appropriate web sites e.g.

http://www.le.ac.uk/pathology/teach/VA/case_2/frmst2.html (virtual autopsy)

http://www.mwrn.com/subject/histonet.htm (histology list server)

http://path.upmc.edu/cases/case183.html (histology cases)

http://www.cap.org/apps/cap.portal?_nfpb=true&_pageLabel=patho_cap_today_page (College of American Pathologists monthly newsletter)

and interactive CD-roms

Reading Strategy

All students will be encouraged to make full use of the print and electronic resources available to them through membership of the University. These include a range of electronic journals and a wide variety of resources available through web sites and information gateways. The University Library’s web pages provide access to subject relevant resources and services, and to the library catalogue. Many resources can be accessed remotely. Students will be presented with opportunities within the curriculum to develop their information retrieval and evaluation skills in order to identify such resources effectively.

This guidance will be available either in the module handbook, via the module information on UWEonline or through any other vehicle deemed appropriate by the module/programme leaders.

Pathology; Stevens and Lowe; Mosby; 1995

Theory and Practice of Histological Techniques; Bancort, J D and Gamble M (Eds); Churchill Livingstone; 2002
Principles and practice of neuropathology; Nelson, Paish, Schochet; Mosby; 1994

Laboratory histopathology; Woods, Ellis; Churchill Livingstone; 1995

Functional histology; Wheater. Burkitt, Dainels; Churchill Livingstone; 1990

Pathology; Rubin and Farben; Lippimott Rava. 1999

Oxford Textbook of Pathology Vols 1, 2a & 2b; Mcgee, Isaacson, Wright; Oxford Medical Publications; 1992

Skeletal muscle pathology; Mastaglia, Walton; Churchill Livingstone; 1992

Diagnostic histopathology of tumours; Fletcher; Churchill Livingstone; 1995

Essential cell biology; Alberts, Bray, Johnson, Lewis, Raff, Roberts, Walter; Garland; 1997

Blood; Palister; Butterworth; 1996

JOURNALS

Histochemistry and Cytochemistry

Histopathology

Histochemical Journal

Journal of Clinical Pathology

Journal of Pathology

Applied Immunohistochemistry and Molecular Morphology

American Journal of Clinical Pathology

The Lancet

Assessment

Weighting between components A and B (standard modules only) A: 50% B: 50%

ATTEMPT 1

First Assessment Opportunity

Component A Element weighting

EX3

Examination ( 3 Hours)

1

     
     
 

 

Component B

Description of each element Element weighting

SM1

Oral seminar plus written synopsis (controlled conditions)

1

   

     
 

 

Second Assessment Opportunity (further attendance at taught classes) No

Component A

Description of each element Element weighting

EX3

Examination ( 3 Hours)

1

     
     
 

 

Component B

Description of each element Element weighting

SM1

Written Presentation of Seminar

1

     
     
 

 

SECOND (OR SUBSEQUENT) ATTEMPT Attendance at taught classes. Yes

Specification confirmed by …………………………………………………Date ……………………………

(Associate Dean/Programme Director)

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