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Date: 05 April 2017
Venue: Lecture Theatre (Room 2B020) UWE, Bristol, Frenchay Campus, Coldharbour Lane, Frenchay, Bristol BS16 1QY
Time: 18:00 - 19:30
Moonlighting metabolons in Alzheimer's disease
Alzheimer's disease (AD) is a progressive condition associated with the production and deposition of amyloid plaques and neurofibrillary tangles, which lead to synaptic and neuronal damage, resulting in memory loss. A significant body of work supports the hypothesis that clearance of amyloid from the brain will improve cognition and delay AD progression. However, recent drug trials, particular to amyloid load, have been disappointing and although amyloid load has been reduced, improved cognition was not observed. In this talk I will explore pathways upstream of aggregate accumulation and discuss how through an understanding of nutrient load and metabolon regulation we may identify new therapeutic targets to delay AD onset. I will also highlight the importance of developing new diagnostics in particular with respect to measuring drug efficacy. Finally, 'The G8 summit sets ambitious 2025 target for dementia cure', always an interesting way to end a discussion.
Myra is Professor of Biomedical Science at UWE, Bristol. She completed her PhD at the National University of Galway, Ireland and was a Research Fellow for 4.5 years at Wake Forest University Medical Centre, USA, which led to her first lecturing post at the University of Brighton, UK. Her research work focuses on understanding fundamental pathways that are dysregulated in Alzheimer's disease (AD) and also on the development of early diagnostics to differentiate between individuals with mild-cognitive impairment and AD.
Her research and collaborative projects have attracted significant research funding resulting in the publication of numerous papers in internationally recognised journals. She is passionate about teaching and training young scientists for careers in research. Myra is Guest Associate Editor for the ebook entitled, “Dysregulation of protein folding in neurodegenerative conditions” and co-editor for the book entitled “Redox-mediated Signal Transduction”. She has a wide range of external peer-review activities and also acts external examiner for degree programmes in Biomedical Science. Myra is a member of the Scientific Advisory Board for BRACE, the ARUK network and the Bristol Dementia Health Integrated team.
Contact: Emma Jefferies
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